Rictor encounters RhoGDI2

Expression profile of RhoGDI2 in lung cancers and role of RhoGDI2 in lung cancer metastasis.

Rho GDP dissociation inhibitors (RhoGDIs) are important regulators of the GTP hydrolase activity and biological functions of Rho GTPases. RhoGDI2 has been shown to be a metastasis suppressor in bladder cancer and several other cancers. However, the underlying mechanism, effector targets, and the cognate biological functions of RhoGDI2 are not fully understood. To investigate the possible role o...

Mechanisms of RhoGDI2 mediated lung cancer epithelial-mesenchymal transition suppression.

BACKGROUND The aim of this study was to evaluate the function of RhoGDI2 in lung cancer epithelial-mesenchymal transition (EMT) process and to illustrate the underlying mechanisms that will lead to improvement of lung cancer treatment. METHODS The RhoGDI2 knock-down and overexpressing A549 cell lines were first constructed. The influence of RhoGDI2 on cytoskeleton in A549 cells was studied us...

Close encounters.

IN THE November issue of Nursing Management, airline pilot Chris Mann asked: 'Safety Culture? What safety culture?' ( Mann 2004 ). His paper summarises the training undertaken in the aviation industry particularly in relation to human factors, in recognition of their part in aviation safety. He posed the following questions of the NHS.

Muscle-Specific Deletion of Rictor Impairs

Numerical simulations of protostellar encounters II . Coplanar disc - disc encounters

It is expected that an average protostar will undergo at least one impulsive interaction with a neighbouring protostar whilst a large fraction of its mass is still in a massive, extended disc. Such interactions must have a significant impact upon the evolution of the protostars and their discs. We have carried out a series of simulations of coplanar encounters between two stars, each possessing...